Development of Pathogenicity‐Driven Definitions of Outcomes for a Field Trial of a Killed Oral Vaccine against EnterotoxigenicEscherichia coliin Egypt: Application of an Evidence‐Based Method | Zendy

John D. Clemens | Zendy; Stephen J. Savarino | Zendy; Remon AbuElyazeed | Zendy; Mohammad Safwat | Zendy; Malla Rao | Zendy; Thomas F. Wierzba | Zendy; A.M. Svennerholm | Zendy; Jan Holmgren | Zendy; Robert W. Frenck | Zendy; Eunsik Park | Zendy; Abdollah Naficy | Zendy

Open Access

Development of Pathogenicity‐Driven Definitions of Outcomes for a Field Trial of a Killed Oral Vaccine against EnterotoxigenicEscherichia coliin Egypt: Application of an Evidence‐Based Method

Author(s) -

John D. Clemens,

Stephen J. Savarino,

Remon AbuElyazeed,

Mohammad Safwat,

Malla Rao,

Thomas F. Wierzba,

A.M. Svennerholm,

Jan Holmgren,

Robert W. Frenck,

Eunsik Park,

Abdollah Naficy

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/386288

Subject(s) - enterotoxigenic escherichia coli , diarrhea , medicine , feces , excretion , odds ratio , bloody diarrhea , vaccination , microbiology and biotechnology , immunology , enterotoxin , biology , escherichia coli , biochemistry , gene

To design an efficacy trial of a killed oral vaccine against enterotoxigenic Escherichia coli (ETEC) diarrhea in Egyptian children, we derived for ETEC diarrhea an empirical definition that increased the probability that diarrhea associated with excretion of ETEC was caused by the detected ETEC.

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