Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1 | Zendy

Jordi Blanch | Zendy; Araceli Rousaud | Zendy; Estebán Martínez | Zendy; Elisa de Lazzari | Zendy; Ana Milinkovic | Zendy; JosepMaria Peri | Zendy; José L. Blanco | Zendy; Juan Javier | Zendy; Vı́ctor Navarro | Zendy; Guillem Massana | Zendy; Josep M. Gatell | Zendy

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Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1

Author(s) -

Jordi Blanch,

Araceli Rousaud,

Estebán Martínez,

Elisa de Lazzari,

Ana Milinkovic,

JosepMaria Peri,

José L. Blanco,

Juan Javier,

Vı́ctor Navarro,

Guillem Massana,

Josep M. Gatell

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/383573

Subject(s) - medicine , lipodystrophy , quality of life (healthcare) , dermatology life quality index , psychosocial , asymptomatic , body mass index , shame , sida , viral disease , human immunodeficiency virus (hiv) , immunology , psychiatry , viral load , disease , antiretroviral therapy , nursing , political science , law

A standardized questionnaire was used to assess the impact of lipodystrophy (LD) on quality of life (QoL). Eighty-four consecutive asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected outpatients with clinical LD completed a modified version of the Dermatology Life Quality Index (DLQI) survey to measure the impact of body fat changes on their QoL. Body changes influenced dressing for 55 patients (65%), produced feelings of shame for 41 (49%), and disrupted sexual life for 23 (27%). There was a greater impact on the DLQI due to body changes among women, injection drug users, patients with abdominal or breast lipoaccumulation, and patients with a high number of non-LD side effects. Multivariate proportional odds model analysis showed that the severity of non-LD-associated side effects and the presence of breast lipoaccumulation were associated with impaired psychosocial functioning. Specific characteristics of patients, antiretroviral-based side effects, and breast lipoaccumulation exert a greater impact on QoL in HIV-1-infected patients with LD.

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