The Hamster as an Animal Model for Eastern Equine Encephalitis—and Its Use in Studies of Virus Entrance into the Brain | Zendy

Slobodan Paessler | Zendy; Patricia Aguilar | Zendy; Michael Anishchenko | Zendy; HuiQun Wang | Zendy; Judith F. Aronson | Zendy; Gerald A. Campbell | Zendy; AnnSophie Cararra | Zendy; Scott C. Weaver | Zendy

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The Hamster as an Animal Model for Eastern Equine Encephalitis—and Its Use in Studies of Virus Entrance into the Brain

Author(s) -

Slobodan Paessler,

Patricia Aguilar,

Michael Anishchenko,

HuiQun Wang,

Judith F. Aronson,

Gerald A. Campbell,

AnnSophie Cararra,

Scott C. Weaver

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/383246

Subject(s) - encephalitis , hamster , viremia , virology , vasculitis , virus , biology , viral encephalitis , immunology , sindbis virus , pathology , medicine , disease , microbiology and biotechnology , rna , biochemistry , gene

Eastern equine encephalitis virus (EEEV) produces the most severe human arboviral diseases in the United States, with mortality rates of 30%-70%. Vasculitis associated with microhemorrhages in the brain dominates the pathological picture in fatal human eastern equine encephalitis, and neuronal cell death is detectable during the late stage of the disease. We describe use of the golden hamster to study EEEV-induced acute vasculitis and encephalitis. In hamsters, EEEV replicates in visceral organs, produces viremia, and penetrates the brain. The pathological manifestations and antigen distribution in the brain of a hamster are similar to those described in human cases of EEEV.

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