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Surfactant protein-D (SP-D), a member of the "collectin" family, has been shown to play a role in innate immunity through modulation of inflammation and clearance of organisms. The role of SP-D in host defense against Pneumocystis carinii pneumonia was assessed using SP-D knockout (KO) mice. When inoculated with P. carinii, both wild-type (wt) and SP-D KO mice required CD4 cell depletion to develop infection. In CD4 cell-depleted models, 2 weeks after infection with P. carinii, SP-D KO mice developed increased intensity of infection, compared with wt mice, despite higher lung-inflammation scores and increased amounts of alveolar inflammatory cells. The increased inflammation seen in SP-D KO mice was accompanied by increases in lung weight, expression of inducible nitric oxide (NO) synthase, total NO levels, and 3-nitrotyrosine levels in lung tissue. These results indicate that SP-D plays a role in host defense against P. carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Delayed Clearance of<i>Pneumocystis carinii</i>Infection, Increased Inflammation, and Altered Nitric Oxide Metabolism in Lungs of Surfactant Protein–D Knockout Mice

Delayed Clearance ofPneumocystis cariniiInfection, Increased Inflammation, and Altered Nitric Oxide Metabolism in Lungs of Surfactant Protein–D Knockout Mice