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Genital herpes is most often transmitted while the patient is asymptomatic, presumably during episodes of viral shedding. To determine whether famciclovir is effective in reducing asymptomatic shedding, women with frequent, recurrent genital outbreaks were enrolled in a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, 112-day trial of suppressive treatment with famciclovir for anogenital viral shedding. Sixty women received 125 mg of famciclovir 3 times daily, 59 received 250 mg of famciclovir 3 times daily, and 58 received placebo. Patients recorded symptoms and self-obtained cultures daily. Famciclovir reduced asymptomatic shedding, compared with placebo (P &lt; .0001). The onset of asymptomatic shedding was also delayed (P &lt; .0001). Famciclovir reduced symptomatic shedding in a dose-dependent manner (0.72% for 125 mg 3 times daily vs. 0.19% for 250 mg 3 times daily [P &lt; .0001] vs. 5.53% for placebo [P &lt; .0001]). In conclusion, suppressive treatment with famciclovir reduced both asymptomatic and symptomatic viral shedding and delayed the onset of asymptomatic shedding in women with frequently recurring genital herpes. Studies to examine the effects of suppression by famciclovir on the transmission of genital herpes are warranted.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Famciclovir Suppression of Asymptomatic and Symptomatic Recurrent Anogenital Herpes Simplex Virus Shedding in Women: A Randomized, Double‐Blind, Double‐Dummy, Placebo‐Controlled, Parallel‐Group, Single‐Center Trial