Phagosomal Acidification Is Not a Prerequisite for Intracellular Multiplication ofLegionella pneumophilain Human Monocytes | Zendy

Hagen Wieland | Zendy; Friedrich Goetz | Zendy; Birgid Neumeister | Zendy

Open Access

Phagosomal Acidification Is Not a Prerequisite for Intracellular Multiplication ofLegionella pneumophilain Human Monocytes

Author(s) -

Hagen Wieland,

Friedrich Goetz,

Birgid Neumeister

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/382894

Subject(s) - legionella pneumophila , legionella , intracellular , microbiology and biotechnology , intracellular parasite , biology , phagosome , monocyte , legionnaires' disease , bacteria , phagocytosis , immunology , genetics

Legionella pneumophila is able to multiply in a variety of eukaryotic cells. Contradictory results have been published on the significance of phagosomal acidification in the intracellular multiplication of Legionella species in monocytes. Therefore, we analyzed the phagosomal pH values in 2 different types of human monocytes throughout the intracellular-replication cycles of 2 Legionella species that have different rates of intracellular multiplication. Our results show that phagosomal acidification is not a prerequisite for intracellular replication of Legionella pneumophila in human monocytes.

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