Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan | Zendy

Fuminaka Sugauchi | Zendy; H Kumada | Zendy; Hiroshi Sakugawa | Zendy; Masashi Komatsu | Zendy; Hiroaki Niitsuma | Zendy; Hisayoshi Watanabe | Zendy; Y. Akahane | Zendy; Hajime Tokita | Zendy; Takanobu Kato | Zendy; Yasuhito Tanaka | Zendy; Etsuro Orito | Zendy; Ryuzo Ueda | Zendy; Y. Miyakawa | Zendy; M Mizokami | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan

Author(s) -

Fuminaka Sugauchi,

H Kumada,

Hiroshi Sakugawa,

Masashi Komatsu,

Hiroaki Niitsuma,

Hisayoshi Watanabe,

Y. Akahane,

Hajime Tokita,

Takanobu Kato,

Yasuhito Tanaka,

Etsuro Orito,

Ryuzo Ueda,

Y. Miyakawa,

M Mizokami

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/382885

Subject(s) - genotype , hepatitis b virus , virology , restriction fragment length polymorphism , restriction enzyme , hepatitis b , virus , orthohepadnavirus , medicine , hepadnaviridae , biology , gene , genetics

We have previously reported 2 subtypes of hepatitis B virus (HBV) genotype B, one of which has the recombination with genotype C over the precore region plus core gene (Ba) and the other of which does not (Bj). A restriction fragment-length polymorphism method with 2 endonucleases was newly developed for distinguishing between subtypes Ba and Bj and was applied to 313 carriers of HBV genotype B in Japan. Subtype Ba was detected in 38 (12%) and subtype Bj in 275 (88%) of the carriers of HBV genotype B. Hepatitis B e antigen in serum was found more frequently in patients with chronic infection with subtype Ba than in those with chronic infection with subtype Bj (8 [32%] of 25 vs. 25 [9%] of 273; P<.01). The new method for distinguishing between Ba and Bj by restriction fragment-length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research