Drug‐Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV‐1–Infected Patient with Disseminated Histoplasmosis | Zendy

Kristel M. L. Crommentuyn | Zendy; Jan W. Mulder | Zendy; Rolf W. Sparidans | Zendy; Alwin D. R. Huitema | Zendy; Jan H.M. Schellens | Zendy; Jos H. Beijnen | Zendy

Open Access

Drug‐Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV‐1–Infected Patient with Disseminated Histoplasmosis

Author(s) -

Kristel M. L. Crommentuyn,

Jan W. Mulder,

Rolf W. Sparidans,

Alwin D. R. Huitema,

Jan H.M. Schellens,

Jos H. Beijnen

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/382675

Subject(s) - itraconazole , ritonavir , lopinavir , medicine , drug , histoplasmosis , pharmacology , drug interaction , virology , lopinavir/ritonavir , immunology , human immunodeficiency virus (hiv) , dermatology , antifungal , antiretroviral therapy , viral load

We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.

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