Open AccessLongitudinal Analysis of Lymphocyte Ratios and HIV‐1 Intracellular DNA Levels in Children
Author(s) -
Akihiko Saitoh,
Christine Powell,
Terence Fenton,
Steven D. Douglas,
Stuart E. Starr,
Courtney V. Fletcher,
Stephen A. Spector
Publication year - 2004
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/382487
Subject(s) - cd4 cd8 ratio , immune system , immunology , intracellular , cd8 , lymphocyte , t lymphocyte , virology , dna , immunopathology , biology , viral disease , human immunodeficiency virus (hiv) , antiretroviral therapy , rna , viral load , lymphocyte subsets , genetics , gene
The associations between human immunodeficiency virus type 1 (HIV-1) intracellular DNA and immunological markers were analyzed longitudinally for children with sustained, undetectable RNA levels while receiving highly active antiretroviral therapy (HAART) for >2 years. When DNA levels reached a plateau at week 104 of therapy, in contrast to findings for adults, there was no correlation between the CD4(+) : CD8(+) ratio and DNA levels (r=-0.02; P=.95), and naive CD4(+)CD45RA(+) lymphocytes predominated. These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults.
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