Synonymous Genetic Polymorphisms within Brazilian Human Immunodeficiency Virus Type 1 Subtypes May Influence Mutational Routes to Drug Resistance | Zendy

Ana Teresa Nogueira Dumans | Zendy; Marcelo A. Soares | Zendy; Elizabeth S. Machado | Zendy; Stéphane Hué | Zendy; Rodrigo Brindeiro | Zendy; Deenan Pillay | Zendy; Amílcar Tanuri | Zendy

Open Access

Synonymous Genetic Polymorphisms within Brazilian Human Immunodeficiency Virus Type 1 Subtypes May Influence Mutational Routes to Drug Resistance

Author(s) -

Ana Teresa Nogueira Dumans,

Marcelo A. Soares,

Elizabeth S. Machado,

Stéphane Hué,

Rodrigo Brindeiro,

Deenan Pillay,

Amílcar Tanuri

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/382483

Subject(s) - drug resistance , biology , virology , reverse transcriptase , mutation , resistance mutation , virus , genetics , gene , polymerase chain reaction

Most published data on antiretroviral-drug resistance is generated from in vitro or in vivo studies of subtype B virus. However, this subtype is associated with <10% of HIV infections worldwide, and it is essential to explore subtype-specific determinants of drug resistance. One potential cause of the differences between subtypes is the synonymous codon usage at key resistance positions.

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