Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand | Zendy

Timothy P. Endy | Zendy; Ananda Nisalak | Zendy; Supamit Chunsuttitwat | Zendy; David W. Vaughn | Zendy; Sharone Green | Zendy; Francis A. Ennis | Zendy; Alan L. Rothman | Zendy; Daniel H. Libraty | Zendy

Open Access

Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand

Author(s) -

Timothy P. Endy,

Ananda Nisalak,

Supamit Chunsuttitwat,

David W. Vaughn,

Sharone Green,

Francis A. Ennis,

Alan L. Rothman,

Daniel H. Libraty

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/382280

Subject(s) - dengue fever , viremia , dengue virus , virology , neutralizing antibody , virus , medicine , immunology , dengue vaccine , antibody , prospective cohort study , viral disease , antibody dependent enhancement

Infection with any 1 of the 4 dengue viruses (DVs) can produce several illnesses, ranging from a mild febrile illness to classic dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood.

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