False‐Positive Galactomannan PlateliaAspergillusTest Results for Patients Receiving Piperacillin‐Tazobactam | Zendy

Claudio Viscoli | Zendy; Marco Machetti | Zendy; Paola Cappellano | Zendy; Barbara Bucci | Zendy; Paolo Bruzzi | Zendy; Maria Teresa Van Lint | Zendy; Andrea Bacigalupo | Zendy

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False‐Positive Galactomannan PlateliaAspergillusTest Results for Patients Receiving Piperacillin‐Tazobactam

Author(s) -

Claudio Viscoli,

Marco Machetti,

Paola Cappellano,

Barbara Bucci,

Paolo Bruzzi,

Maria Teresa Van Lint,

Andrea Bacigalupo

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/382224

Subject(s) - medicine , galactomannan , piperacillin/tazobactam , gastroenterology , piperacillin , multivariate analysis , tazobactam , aspergillosis , immunology , pseudomonas aeruginosa , bacteria , genetics , biology

At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P<.001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.

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