Antigen Genes for Molecular Epidemiology of Leishmaniasis: Polymorphism of Cysteine Proteinase B and Surface Metalloprotease Glycoprotein 63 in theLeishmaniadonovaniComplex
Author(s) -
Kelly Wilber Quispe Tintaya,
Xu Ying,
JeanPierre Dedet,
Suman Rijal,
Xavier De Bolle,
JeanClaude Dujardin
Publication year - 2004
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/382049
Subject(s) - biology , restriction fragment length polymorphism , leishmania donovani , locus (genetics) , visceral leishmaniasis , typing , antigen , polymerase chain reaction , leishmaniasis , genotyping , leishmania braziliensis , gene , microbiology and biotechnology , genetics , virology , cutaneous leishmaniasis , genotype
Efficient monitoring of endemic and resurgent visceral leishmaniasis (VL) requires discriminatory molecular tools that allow direct characterization of etiological agents (i.e., the Leishmania donovani complex) in host tissues. This characterization is possible through restriction fragment-length polymorphism (RFLP) analysis of polymerase chain reaction (PCR)-amplified sequences (PCR-RFLP).
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