Serologic Response and Antibody‐Titer Decay in Adults with Pertussis | Zendy

Ulrich Heininger | Zendy; James D. Cherry | Zendy; K Stehr | Zendy

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Serologic Response and Antibody‐Titer Decay in Adults with Pertussis

Author(s) -

Ulrich Heininger,

James D. Cherry,

K Stehr

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/381439

Subject(s) - filamentous haemagglutinin adhesin , bordetella pertussis , pertactin , medicine , pertussis toxin , serology , whooping cough , pertussis vaccine , immunology , antibody , antibody titer , vaccination , titer , virology , immunization , biology , g protein , receptor , bacteria , genetics

Pertussis is a frequent and significant illness in adults. Because acellular pertussis vaccines for use in adolescents and adults have now been developed, it is important to compare serologic responses in adults after infection with serologic responses in adults after vaccination. We measured IgG and IgA antibodies to 4 Bordetella pertussis antigens at approximately 6-month intervals for 28 months in 11 adults with pertussis. After reaching peak levels, titers of antibody to pertussis toxin decreased more than did titers of antibodies to filamentous hemagglutinin, pertactin, and fimbriae type 1 and type 2. Although studies of adults who have been vaccinated with acellular pertussis vaccines have had shorter follow-up periods than studies of adults with pertussis infection, the antibody decay patterns are similar in both groups.

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