Dihydrofolate Reductase Mutations inPlasmodium vivaxfrom Indonesia and Therapeutic Response to Sulfadoxine plus Pyrimethamine | Zendy

Michele D. Hastings | Zendy; Kathryn M. Porter | Zendy; Jason D. Maguire | Zendy; Ika Yuni Susanti | Zendy; Winni Kania | Zendy; Michael J. Bangs | Zendy; Carol Hopkins Sibley | Zendy; J. Kevin Baird | Zendy

Open Access

Dihydrofolate Reductase Mutations inPlasmodium vivaxfrom Indonesia and Therapeutic Response to Sulfadoxine plus Pyrimethamine

Author(s) -

Michele D. Hastings,

Kathryn M. Porter,

Jason D. Maguire,

Ika Yuni Susanti,

Winni Kania,

Michael J. Bangs,

Carol Hopkins Sibley,

J. Kevin Baird

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/381397

Subject(s) - pyrimethamine , dihydrofolate reductase , plasmodium vivax , biology , allele , sulfadoxine , antifolate , virology , genetics , immunology , malaria , chloroquine , plasmodium falciparum , gene , chemotherapy , antimetabolite

The target enzyme of pyrimethamine is dihydrofolate reductase (DHFR), but little is known about allelic variants of dhfr in Plasmodium vivax populations. Still less is known about associations between specific alleles and the failure of sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo.

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