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The target enzyme of pyrimethamine is dihydrofolate reductase (DHFR), but little is known about allelic variants of dhfr in Plasmodium vivax populations. Still less is known about associations between specific alleles and the failure of sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo.

Dihydrofolate Reductase Mutations inPlasmodium vivaxfrom Indonesia and Therapeutic Response to Sulfadoxine plus Pyrimethamine