Induction of Cellular and Humoral Immunity after Aerosol or Subcutaneous Administration of Edmonston‐Zagreb Measles Vaccine as a Primary Dose to 12‐Month‐Old Children | Zendy

Rosa María WongChew | Zendy; Rocı́o Islas-Romero | Zendy; Lourdes GarcíaGarcía | Zendy; Judy A. Beeler | Zendy; Susette Audet | Zendy; José Ignacio Santos-Preciado | Zendy; Hayley A. Gans | Zendy; Linda LewYasukawa | Zendy; Yvonne Maldonado | Zendy; Ann M. Arvin | Zendy; José Luis ValdespinoGómez | Zendy

Open Access

Induction of Cellular and Humoral Immunity after Aerosol or Subcutaneous Administration of Edmonston‐Zagreb Measles Vaccine as a Primary Dose to 12‐Month‐Old Children

Author(s) -

Rosa María WongChew,

Rocı́o Islas-Romero,

Lourdes GarcíaGarcía,

Judy A. Beeler,

Susette Audet,

José Ignacio Santos-Preciado,

Hayley A. Gans,

Linda LewYasukawa,

Yvonne Maldonado,

Ann M. Arvin,

José Luis ValdespinoGómez

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/380565

Subject(s) - medicine , measles , measles vaccine , seroconversion , vaccination , immunogenicity , immunology , measles virus , virology , immunity , immunization , immune system , antibody

Infants were immunized by aerosol (10(3.6) plaque-forming units [pfu]/dose) or subcutaneous (sc) (10(4.27) pfu/dose) administration of Edmonston-Zagreb measles vaccine. Measles-specific T cell proliferative responses with a stimulation index of > or =3 developed in 72% of children given aerosol-administered vaccine, compared with 87% given s.c.-administered vaccine (P =.06). Seroconversion rates were 90% after aerosol-administered vaccine and 100% after s.c.-administered vaccine (P=.01), and measles geometric mean titers were 237 milli-international units (mIU) (95% confidence interval [CI], 146-385 mIU) and 487 mIU (95% CI, 390-609 mIU) in each group, respectively (P=.01). Measles-specific T and B cell responses were weaker after aerosol than after sc vaccination, indicating a need to use a higher aerosol dose to achieve optimal immunogenicity.

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