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Antibodies to the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) glycoprotein 120 (gp120) inhibit gp120 antigen presentation to CD4 T cells. These findings imply that the presence of anti-CD4bd antibodies might contribute to the dearth of envelope-specific T helper responses observed in most HIV-1-positive patients. In the absence of these antibodies, however, anti-envelope T helper responses might be maintained.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

HIV‐1–Infected Patients with Envelope‐Specific Lymphoproliferation or Long‐Term Nonprogression Lack Antibodies Suppressing Glycoprotein 120 Antigen Presentation