HIV‐1–Infected Patients with Envelope‐Specific Lymphoproliferation or Long‐Term Nonprogression Lack Antibodies Suppressing Glycoprotein 120 Antigen Presentation | Zendy

Peter Chien | Zendy; Daniel Chen | Zendy; Peide Chen | Zendy; Michael Tuen | Zendy; Sandra Cohen | Zendy; Stephen A. Migueles | Zendy; Mark Connors | Zendy; Eric Rosenberg | Zendy; Uma Malhotra | Zendy; Charles J. Gonzalez | Zendy; Catarina E. Hioe | Zendy

Open Access

HIV‐1–Infected Patients with Envelope‐Specific Lymphoproliferation or Long‐Term Nonprogression Lack Antibodies Suppressing Glycoprotein 120 Antigen Presentation

Author(s) -

Peter Chien,

Daniel Chen,

Peide Chen,

Michael Tuen,

Sandra Cohen,

Stephen A. Migueles,

Mark Connors,

Eric Rosenberg,

Uma Malhotra,

Charles J. Gonzalez,

Catarina E. Hioe

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/380133

Subject(s) - antibody , immunology , biology , antigen , virology , glycoprotein , titer , immunopathology , antibody titer , microbiology and biotechnology

Antibodies to the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) glycoprotein 120 (gp120) inhibit gp120 antigen presentation to CD4 T cells. These findings imply that the presence of anti-CD4bd antibodies might contribute to the dearth of envelope-specific T helper responses observed in most HIV-1-positive patients. In the absence of these antibodies, however, anti-envelope T helper responses might be maintained.

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