Pathogenetic Tropism of Varicella‐Zoster Virus to Primary Human Hepatocytes and Attenuating Tropism of Oka Varicella Vaccine Strain to Neonatal Dermal Fibroblasts | Zendy

Kimíyasu Shiraki | Zendy; Yoshihiro Yoshida | Zendy; Yoshizo Asano | Zendy; Koichi Yamanishi | Zendy; Michiaki Takahashi | Zendy

Open Access

Pathogenetic Tropism of Varicella‐Zoster Virus to Primary Human Hepatocytes and Attenuating Tropism of Oka Varicella Vaccine Strain to Neonatal Dermal Fibroblasts

Author(s) -

Kimíyasu Shiraki,

Yoshihiro Yoshida,

Yoshizo Asano,

Koichi Yamanishi,

Michiaki Takahashi

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/379835

Subject(s) - tropism , virology , varicella zoster virus , virus , tissue tropism , pathogenesis , biology , medicine , immunology

The pathogenesis of varicella-zoster virus (VZV) was characterized by the cell tropism of the original Oka and attenuated Oka varicella vaccine strains. Among the tissue cells examined, VZV replicated best in hepatocytes and second best in lung fibroblasts. The high affinity to hepatocytes and lung fibroblasts might correlate with varicella hepatitis and pneumonia and with autopsy observations of varicella. Cell tropism may be important in understanding the pathogenesis of VZV.

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