Quantification of Human T‐Lymphotropic Virus Type I (HTLV‐I) Provirus Load in a Rural West African Population: No Enhancement of Human Immunodeficiency Virus Type 2 Pathogenesis, but HTLV‐I Provirus Load Relates to Mortality | Zendy

Koya Ariyoshi | Zendy; Neil G. Berry | Zendy; Fatim Cham | Zendy; Shabbar Jaffar | Zendy; Maarten Schim van der Loeff | Zendy; Ousman Jobe | Zendy; Pa Tamba N’Gom | Zendy; Olav Larsen | Zendy; Sören Andersson | Zendy; Peter Aaby | Zendy; Hilton Whittle | Zendy

Open Access

Quantification of Human T‐Lymphotropic Virus Type I (HTLV‐I) Provirus Load in a Rural West African Population: No Enhancement of Human Immunodeficiency Virus Type 2 Pathogenesis, but HTLV‐I Provirus Load Relates to Mortality

Author(s) -

Koya Ariyoshi,

Neil G. Berry,

Fatim Cham,

Shabbar Jaffar,

Maarten Schim van der Loeff,

Ousman Jobe,

Pa Tamba N’Gom,

Olav Larsen,

Sören Andersson,

Peter Aaby,

Hilton Whittle

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/379780

Subject(s) - provirus , coinfection , virology , human t lymphotropic virus , viral load , virus , population , immunology , human t lymphotropic virus 1 , biology , medicine , genetics , environmental health , gene , t cell leukemia , genome , myelopathy , neuroscience , spinal cord

Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

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