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Genome-derived neisserial antigen 2132 (GNA2132) is a novel vaccine candidate that was identified during the Neisseria meningitidis group B strain MC58 genome-sequencing project. To assess the vaccine potential of GNA2132, we prepared antisera from mice immunized with recombinant GNA2132 (gene from strain NZ394/98). Anti-GNA2132 antibody bound to the surface of live bacteria from all 7 capsular group B or C strains tested and elicited deposition of human C3b on the bacterial surface. However, with human or infant-rat complement, anti-GNA2132 had no detectable bactericidal activity (titer, &lt;1:4) against the nominal strain, NZ394/98, and was bactericidal against only 2 of the other 6 strains tested. These differences between strains were unrelated to GNA2132 amino acid sequence or level of protein expression. Despite lack of bactericidal activity, anti-GNA2132 antiserum passively protected infant rats against meningococcal bacteremia after challenge with all 5 resistant strains. GNA2132 is thus a promising vaccine candidate for prevention of disease caused by N. meningitidis.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Antibody to Genome‐Derived Neisserial Antigen 2132, a<i>Neisseria meningitidis</i>Candidate Vaccine, Confers Protection against Bacteremia in the Absence of Complement‐Mediated Bactericidal Activity

Antibody to Genome‐Derived Neisserial Antigen 2132, aNeisseria meningitidisCandidate Vaccine, Confers Protection against Bacteremia in the Absence of Complement‐Mediated Bactericidal Activity