Interferon‐γ Response by Peripheral Blood Mononuclear Cells to Hepatitis C Virus Core Antigen Is Reduced in Patients with Liver Fibrosis | Zendy

Mark Watson | Zendy; Aleksandra Jaksic | Zendy; Patricia Price | Zendy; Wendy Cheng | Zendy; Marian McInerney | Zendy; Martyn A. French | Zendy; Scott Fisher | Zendy; Silvia Lee | Zendy; James Flexman | Zendy

Open Access

Interferon‐γ Response by Peripheral Blood Mononuclear Cells to Hepatitis C Virus Core Antigen Is Reduced in Patients with Liver Fibrosis

Author(s) -

Mark Watson,

Aleksandra Jaksic,

Patricia Price,

Wendy Cheng,

Marian McInerney,

Martyn A. French,

Scott Fisher,

Silvia Lee,

James Flexman

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/379252

Subject(s) - peripheral blood mononuclear cell , fibrosis , medicine , immunology , antigen , hepatitis c virus , hepatitis c , interferon , hepatitis , cytomegalovirus , liver disease , interferon gamma , virology , virus , pathology , viral disease , cytokine , herpesviridae , biology , biochemistry , in vitro

Liver fibrosis was correlated with immunological parameters. Peripheral blood mononuclear cells (PBMCs) from patients with low fibrosis scores had more [corrected] interferon (IFN)-gamma-producing cells than did patients with higher fibrosis scores, when stimulated with hepatitis C virus (HCV) core antigen. Irrespective of liver fibrosis score, cells from all cytomegalovirus (CMV)-seropositive patients had similar IFN-gamma responses, when stimulated by CMV antigen, so patients with fibrosis did not have a broad-spectrum immunodeficiency. IFN-gamma response by PBMCs to HCV core antigen may provide a useful marker of the severity of liver disease in patients with hepatitis C.

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