Invasive Pneumococcal Disease in Scotland, 1999-2001: Use of Record Linkage to Explore Associations between Patients and Disease in Relation to Future Vaccination Policy | Zendy

Moe H. Kyaw | Zendy; P Christie | Zendy; Stuart C. Clarke | Zendy; John D. Mooney | Zendy; S. Faisal Ahmed | Zendy; IG Jones | Zendy; Harry Campbell | Zendy

Open Access

Invasive Pneumococcal Disease in Scotland, 1999-2001: Use of Record Linkage to Explore Associations between Patients and Disease in Relation to Future Vaccination Policy

Author(s) -

Moe H. Kyaw,

P Christie,

Stuart C. Clarke,

John D. Mooney,

S. Faisal Ahmed,

IG Jones,

Harry Campbell

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/379016

Subject(s) - medicine , case fatality rate , vaccination , disease , pneumococcal disease , medical record , pediatrics , incidence (geometry) , immunosuppression , record linkage , pneumococcal polysaccharide vaccine , pneumococcal vaccine , pneumococcal conjugate vaccine , pneumococcal infections , epidemiology , demography , immunology , environmental health , streptococcus pneumoniae , antibiotics , population , sociology , physics , optics , microbiology and biotechnology , biology

A record linkage study was done to provide comprehensive data on the epidemiologic characteristics of invasive pneumococcal disease (IPD) in Scotland. The overall incidence of IPD was 11 cases/10(5) persons and 21 cases/10(5) persons <1 year of age, 51 cases/10(5) persons 1 year of age, 45 cases/10(5) elderly persons (age > or =65 years), 176-483 cases/10(5) persons with chronic medical conditions, and 562-2031 cases/10(5) persons with severe immunosuppression. The case-fatality rate was 11% among elderly persons and ranged from 3% to 13% among persons with underlying medical conditions. The most common pneumococcal serogroups associated with IPD were 14, 9, 6, 19, 23, 8, and 4. Serogroups included in the 23-valent polysaccharide vaccine caused the majority of cases of IPD. The proportion of IPD due to the 7-, 9-, and 11-valent conjugate vaccine serogroups was lower among older people and persons with underlying medical conditions.

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