Linezolid-Associated Toxic Optic Neuropathy: A Report of 2 Cases | Zendy

Eunjung Lee | Zendy; Scott R. Burger | Zendy; Casey Melton | Zendy; Michael P. Mullen | Zendy; Floyd A. Warren | Zendy; Robert H. Press | Zendy

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Linezolid-Associated Toxic Optic Neuropathy: A Report of 2 Cases

Author(s) -

Eunjung Lee,

Scott R. Burger,

Casey Melton,

Michael P. Mullen,

Floyd A. Warren,

Robert H. Press

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/379012

Subject(s) - linezolid , medicine , optic neuropathy , staphylococcus aureus , blurred vision , surgery , ophthalmology , optic nerve , vancomycin , bacteria , biology , genetics

We describe 2 cases in which the prolonged use of linezolid to treat complicated methicillin-resistant Staphylococcus aureus infections was followed by acutely developed blurred vision and progressive loss of vision and color perception during the ensuing few weeks. Both patients received a diagnosis of toxic optic neuropathy, and linezolid therapy was stopped. The patients experienced an initial rapid partial improvement and a subsequent gradual, almost complete, recovery over many months.

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