Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome | Zendy

Wei Cui | Zendy; Ying Fan | Zendy; Wei Wu | Zendy; Feng Zhang | Zendy; Junying Wang | Zendy; Anping Ni | Zendy

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Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

Author(s) -

Wei Cui,

Ying Fan,

Wei Wu,

Feng Zhang,

Junying Wang,

Anping Ni

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/378587

Subject(s) - lymphocyte , leukopenia , immunology , medicine , cd8 , immune system , respiratory system , severe acute respiratory syndrome , t lymphocyte , lymphocytopenia , lymphocyte subsets , covid-19 , toxicity , disease , infectious disease (medical specialty)

In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4(+) T lymphocyte levels were reduced in 100% of patients, CD8(+) T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.

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