Dilated Cardiomyopathy in an Adult Human Immunodeficiency Virus Type 1-Positive Patient Treated with a Zidovudine-Containing Antiretroviral Regime | Zendy

Junko Tanuma | Zendy; Akiko Ishizaki | Zendy; Hiroyuki Gatanaga | Zendy; Yoshimi Kikuchi | Zendy; Satoshi Kimura | Zendy; Michiaki Hiroe | Zendy; Shinichi Oka | Zendy

Open Access

Dilated Cardiomyopathy in an Adult Human Immunodeficiency Virus Type 1-Positive Patient Treated with a Zidovudine-Containing Antiretroviral Regime

Author(s) -

Junko Tanuma,

Akiko Ishizaki,

Hiroyuki Gatanaga,

Yoshimi Kikuchi,

Satoshi Kimura,

Michiaki Hiroe,

Shinichi Oka

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/377609

Subject(s) - nelfinavir , zidovudine , medicine , lamivudine , dilated cardiomyopathy , abacavir , cardiomyopathy , indinavir , virology , discontinuation , nucleoside analogue , regimen , viral disease , sida , human immunodeficiency virus (hiv) , viral load , nucleoside , virus , heart failure , antiretroviral therapy , biology , biochemistry , hepatitis b virus

We describe an adult woman infected with human immunodeficiency virus type 1 (HIV-1) who developed dilated cardiomyopathy (DCM) with histologically confirmed mitochondrial damage while receiving anti-HIV-1 combination therapy that included nelfinavir, lamivudine, and zidovudine. DCM resolved after discontinuation of the regimen, and cardiac function remained normal after initiation of treatment with nelfinavir, lamivudine, and abacavir, which indicates that DCM was induced by mitochondrial toxicity, most likely caused by zidovudine.

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