Phylogenetic Origin and Virulence Genotype in Relation to Resistance to Fluoroquinolones and/or Extended‐Spectrum Cephalosporins and Cephamycins amongEscherichia coliIsolates from Animals and Humans | Zendy

James R. Johnson | Zendy; Michael A. Kuskowski | Zendy; Krista Owens | Zendy; Abby Gajewski | Zendy; Patricia Winokur | Zendy

Open Access

Phylogenetic Origin and Virulence Genotype in Relation to Resistance to Fluoroquinolones and/or Extended‐Spectrum Cephalosporins and Cephamycins amongEscherichia coliIsolates from Animals and Humans

Author(s) -

James R. Johnson,

Michael A. Kuskowski,

Krista Owens,

Abby Gajewski,

Patricia Winokur

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/377455

Subject(s) - virulence , biology , phylogenetic tree , microbiology and biotechnology , context (archaeology) , cephalosporin , escherichia coli , genotype , antibiotic resistance , phylogenetics , virology , genetics , antibiotics , gene , paleontology

In Escherichia coli infection, the implications of fluoroquinolone (FQ) and extended-spectrum cephalosporin plus cephamycin (AmpC) resistance for phylogenetic origin and virulence potential are undefined, as is the influence of ecological context on these associations. Accordingly, 106 E. coli isolates exhibiting FQ and/or AmpC resistance and 98 susceptible isolates were compared with regard to phylogenetic background and virulence profiles, stratified by host group (104 predominantly extraintestinal human isolates and 100 predominantly intestinal cattle and swine isolates). Although resistant isolates exhibited significant shifts in phylogenetic distribution and virulence profiles, human and animal isolates exhibited different phylogenetic shifts, and only among human isolates did resistance predict reduced virulence. Evidence for similar strains being resistant versus susceptible was scant. The O15:K52:H1 clonal group and the closely related "clonal group A" featured prominently among resistant and susceptible human isolates, respectively. Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research