Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation | Zendy

ManFung Yuen | Zendy; Erwin Sablon | Zendy; Danny KaHo Wong | Zendy; HeJun Yuan | Zendy; Benjamin Chun–Yu Wong | Zendy; Annie OnOn Chan | Zendy; ChingLung Lai | Zendy

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Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation

Author(s) -

ManFung Yuen,

Erwin Sablon,

Danny KaHo Wong,

HeJun Yuan,

Benjamin Chun–Yu Wong,

Annie OnOn Chan,

ChingLung Lai

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/376988

Subject(s) - medicine , genotype , hepatitis b virus , exacerbation , decompensation , hepatitis b , gastroenterology , liver disease , bilirubin , virology , immunology , virus , gene , biology , biochemistry

Hepatitis B virus (HBV) genotypes and precore and core promoter mutations were determined in 318 patients with HBV. Patients infected with HBV genotype B had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with HBV genotype C (all P<.001). By logistic regression analysis, HBV genotype B infection (P=.014) and low albumin levels (P=.006) were independently associated with a higher risk of hepatic decompensation during severe exacerbations of disease. Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P=.05).

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