Studies of Adipose Tissue Metabolism in Human Immunodeficiency Virus–Associated Lipodystrophy | Zendy

Donald P. Kotler | Zendy; Gabriel Ionescu | Zendy; Julia A. Johnson | Zendy; Yori Inada | Zendy; Qing He | Zendy; Ellen S. Engelson | Zendy; Jeanine Albu | Zendy

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Studies of Adipose Tissue Metabolism in Human Immunodeficiency Virus–Associated Lipodystrophy

Author(s) -

Donald P. Kotler,

Gabriel Ionescu,

Julia A. Johnson,

Yori Inada,

Qing He,

Ellen S. Engelson,

Jeanine Albu

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/375891

Subject(s) - lipodystrophy , adipose tissue , medicine , lipoatrophy , tumor necrosis factor alpha , endocrinology , immunology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy

We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)-infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.

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