Pseudoneoplastic Appearance of Cytomegalovirus-Associated Colitis in Nonimmunocompromised Patients: Report of 2 Cases | Zendy

Antonino Maiorana | Zendy; Pietro Torricelli | Zendy; Francesca Giusti | Zendy; N Bellini | Zendy

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Pseudoneoplastic Appearance of Cytomegalovirus-Associated Colitis in Nonimmunocompromised Patients: Report of 2 Cases

Author(s) -

Antonino Maiorana,

Pietro Torricelli,

Francesca Giusti,

N Bellini

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/375876

Subject(s) - medicine , colonoscopy , granulation tissue , cytomegalovirus , colitis , pathology , diarrhea , colectomy , human cytomegalovirus , abdominal pain , lesion , virus , viral disease , immunology , herpesviridae , gastroenterology , ulcerative colitis , wound healing , colorectal cancer , disease , cancer

Two cases of human cytomegalovirus (HCMV) colitis with pseudoneoplastic appearance are described. Patients presented with abdominal pain, fever, and diarrhea. Colonoscopy revealed a stenosing lesion in one patient and a broad-based, vegetant mass in the other patient, and histopathological examination of colectomy specimens revealed exuberant inflammatory masses with infiltration of mononuclear cells and ulcers with granulation tissue. Typical intranuclear HCMV inclusions were numerous. Peculiar to both patients was the lack of any apparent causes of immunodeficiency, such as human immunodeficiency virus infection or previous organ transplantation.

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