Genetic Confirmation of Atovaquone-Proguanil-Resistant Plasmodium falciparum Malaria Acquired by a Nonimmune Traveler to East Africa | Zendy

Eli Schwartz | Zendy; Sergey Bujanover | Zendy; Kevin C. Kain | Zendy

Open Access

Genetic Confirmation of Atovaquone-Proguanil-Resistant Plasmodium falciparum Malaria Acquired by a Nonimmune Traveler to East Africa

Author(s) -

Eli Schwartz,

Sergey Bujanover,

Kevin C. Kain

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/375599

Subject(s) - atovaquone , proguanil , malaria , plasmodium falciparum , medicine , virology , immunology

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

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