Diagnosis of Enterovirus Infection in the First 2 Months of Life by Real-Time Polymerase Chain Reaction | Zendy

M A Verboon-Maciolek | Zendy; Monique Nijhuis | Zendy; Anton M. van Loon | Zendy; N. van Maarssenveen | Zendy; Hester van Wieringen | Zendy; Martha PekelharingBerghuis | Zendy; Tannette G. Krediet | Zendy; Leo J. Gerards | Zendy; A. Fleer | Zendy; R. J. A. Diepersloot | Zendy; Steven Thijsen | Zendy

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Diagnosis of Enterovirus Infection in the First 2 Months of Life by Real-Time Polymerase Chain Reaction

Author(s) -

M A Verboon-Maciolek,

Monique Nijhuis,

Anton M. van Loon,

N. van Maarssenveen,

Hester van Wieringen,

Martha PekelharingBerghuis,

Tannette G. Krediet,

Leo J. Gerards,

A. Fleer,

R. J. A. Diepersloot,

Steven Thijsen

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/375222

Subject(s) - medicine , enterovirus , incidence (geometry) , sepsis , enterovirus 71 , pediatrics , neonatal intensive care unit , intensive care unit , polymerase chain reaction , feces , immunology , virus , microbiology and biotechnology , biochemistry , physics , chemistry , biology , optics , gene

During summer and fall, enterovirus infections are responsible for a considerable proportion of hospitalizations of young infants. We prospectively studied the incidence of enterovirus infections via real-time polymerase chain reaction (PCR) in blood, feces, and cerebrospinal fluid samples from infants <or=60 days old who had received a clinical diagnosis of sepsis. Forty-five patients were included: 19 were admitted to the pediatric wards of 2 general hospitals, and 26 had been hospitalized since birth in the neonatal intensive care unit (NICU) of a tertiary care hospital. None of the NICU patients developed enteroviral disease. In contrast, an enterovirus was detected in 11 (58%) of the patients admitted to the 2 general hospitals, 10 of whom (53%) showed evidence of systemic infection. Enterovirus infections are an important cause of sepsis in infants admitted to the hospital. Real-time PCR in serum was a rapid and sensitive method for diagnosis of enterovirus infection.

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