Clearance of 14-3-3 Protein from Cerebrospinal Fluid Heralds the Resolution of Bacterial Meningitis | Zendy

Stefano Bonora | Zendy; Gianluigi Zanusso | Zendy; Riccardo Raiteri | Zendy; Salvatore Monaco | Zendy; Antonella Rossati | Zendy; Sérgio Ferrari | Zendy; Marta Boffito | Zendy; Sabrina Audagnotto | Zendy; Alessandro Sinicco | Zendy; Nicola Rizzuto | Zendy; Ercole Concia | Zendy; Giovanni Di Perri | Zendy

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Clearance of 14-3-3 Protein from Cerebrospinal Fluid Heralds the Resolution of Bacterial Meningitis

Author(s) -

Stefano Bonora,

Gianluigi Zanusso,

Riccardo Raiteri,

Salvatore Monaco,

Antonella Rossati,

Sérgio Ferrari,

Marta Boffito,

Sabrina Audagnotto,

Alessandro Sinicco,

Nicola Rizzuto,

Ercole Concia,

Giovanni Di Perri

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/375066

Subject(s) - clearance , cerebrospinal fluid , medicine , meningitis , csf albumin , bacterial meningitis , central nervous system disease , pathology , gastroenterology , surgery , urology

The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.

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