Outbreak of Tuberculosis Among Homeless Persons Coinfected with Human Immunodeficiency Virus | Zendy

Peter D. McElroy | Zendy; K Southwick | Zendy; Ellen R. Fortenberry | Zendy; Elizabeth Levine | Zendy; Lois Diem | Zendy; Charles L. Woodley | Zendy; Paula M. Williams | Zendy; Kimberly D. McCarthy | Zendy; Renée Ridzon | Zendy; Peter A. Leone | Zendy

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Outbreak of Tuberculosis Among Homeless Persons Coinfected with Human Immunodeficiency Virus

Author(s) -

Peter D. McElroy,

K Southwick,

Ellen R. Fortenberry,

Elizabeth Levine,

Lois Diem,

Charles L. Woodley,

Paula M. Williams,

Kimberly D. McCarthy,

Renée Ridzon,

Peter A. Leone

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/374836

Subject(s) - tuberculosis , medicine , mycobacterium tuberculosis , transmission (telecommunications) , outbreak , epidemiology , typing , dna profiling , virology , retrospective cohort study , index case , cluster (spacecraft) , contact tracing , molecular epidemiology , cohort , attendance , genotype , disease , microbiology and biotechnology , pathology , biology , dna , infectious disease (medical specialty) , covid-19 , genetics , economic growth , computer science , engineering , programming language , electrical engineering , economics , gene

We investigated a cluster of patients with tuberculosis (TB) in North Carolina and determined the extent of transmission of 1 strain of Mycobacterium tuberculosis. A retrospective cohort study was conducted. Homeless shelter attendance and medical records for 1999 and 2000 were reviewed. The period of exposure to M. tuberculosis was determined, and shelter residents were offered TB screening. DNA fingerprinting was performed on 72 M. tuberculosis isolates. In addition to the initial index cluster of 9 patients, another 16 patients were identified. Isolates of M. tuberculosis from all 25 patients shared a matching DNA fingerprint pattern. All but 1 patient was male, 22 (88%) were African American, and 14 (56%) were human immunodeficiency virus-infected. An epidemiological link to a single shelter was identified for all but 1 patient. Earlier recognition of this shelter as a site of M. tuberculosis transmission could have been facilitated through innovative approaches to contact investigation and through genetic typing of isolates.

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