Epstein‐Barr Virus and Human Herpesvirus 8 Coinfection and Concomitant Extranodal Nasal‐Type NK/T Cell Lymphoma and Castleman Disease: Case Report | Zendy

C. Larroche | Zendy; F. Agbalika | Zendy; Hélène A. Poirel | Zendy; Antoine Martin | Zendy; Agnès GautheretDejean | Zendy; Martine Raphaël | Zendy; Olivier Lortholary | Zendy

Open Access

Epstein‐Barr Virus and Human Herpesvirus 8 Coinfection and Concomitant Extranodal Nasal‐Type NK/T Cell Lymphoma and Castleman Disease: Case Report

Author(s) -

C. Larroche,

F. Agbalika,

Hélène A. Poirel,

Antoine Martin,

Agnès GautheretDejean,

Martine Raphaël,

Olivier Lortholary

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/374663

Subject(s) - medicine , lymphoma , virus , pathology , epstein–barr virus , coinfection , virology , immunology , peripheral blood mononuclear cell , castleman disease , herpesviridae , t cell lymphoma , disease , viral disease , biology , biochemistry , in vitro

We describe a 36-year-old man uninfected with human immunodeficiency virus who had confirmed concurrent infection with Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) and their respective lymphoproliferative manifestations, nasal-type NK/T cell lymphoma and Castleman disease. Antibodies to HHV-8 and EBV DNA were found in plasma and peripheral blood mononuclear cells. An EBV-positive nasal-type NK/T cell lymphoma infiltrated the splenic red pulp, whereas the white pulp contained HHV-8-positive plasmablasts, as found in Castleman disease.

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