Relationship of Kaposi Sarcoma (KS)–Associated Herpesvirus Viremia and KS Disease in Zimbabwe | Zendy

Thomas Campbell | Zendy; Margaret Borok | Zendy; I. White | Zendy; Ivy Gudza | Zendy; Buxton Ndemera | Zendy; Albert Taziwa | Zendy; Adriana Weinberg | Zendy; Lovemore Gwanzura | Zendy

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Relationship of Kaposi Sarcoma (KS)–Associated Herpesvirus Viremia and KS Disease in Zimbabwe

Author(s) -

Thomas Campbell,

Margaret Borok,

I. White,

Ivy Gudza,

Buxton Ndemera,

Albert Taziwa,

Adriana Weinberg,

Lovemore Gwanzura

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/374599

Subject(s) - viremia , virology , immunology , viral disease , lytic cycle , medicine , peripheral blood mononuclear cell , concomitant , viral load , virus , serology , kaposi's sarcoma associated herpesvirus , herpesviridae , biology , antibody , in vitro , biochemistry

The relationship between Kaposi sarcoma-associated herpesvirus (KSHV) viremia and KS disease was investigated in 500 subjects who received treatment in Harare, Zimbabwe. Subjects were grouped by results of human immunodeficiency virus (HIV) type 1 serological tests, KS diagnosis, and KS clinical stage. The plasma KSHV DNA concentration was associated with concomitant KS and HIV-1 infection (AIDS-KS; P<.001) and AIDS-KS clinical stage (P=.01). Plasma KSHV DNA levels were greater in AIDS-KS than in matched HIV-1-seronegative KS (P=.04). The plasma KSHV DNA level was not associated with age, sex, systemic symptoms, or CD4+ lymphocyte count. Plasma and peripheral blood mononuclear cell KSHV DNA concentrations were linearly related (r2=.44; P<.001), and the nucleotide sequence of the K1 gene highly variable region was identical in both compartments. These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection.

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