Incidence of Acquired Immunodeficiency Syndrome–Associated Opportunistic Diseases and the Effect of Treatment on a Cohort of 1115 Patients Infected with Human Immunodeficiency Virus, 1989–1997 | Zendy

FranciscoJavier SanAndres | Zendy; Rafael Rubio | Zendy; Jesús Castilla | Zendy; Federico Pulido | Zendy; Guillermo Palao | Zendy; Inmaculada de la Serna de Pedro | Zendy; JoseRamon Costa | Zendy; A del Palacio | Zendy

Open Access

Incidence of Acquired Immunodeficiency Syndrome–Associated Opportunistic Diseases and the Effect of Treatment on a Cohort of 1115 Patients Infected with Human Immunodeficiency Virus, 1989–1997

Author(s) -

FranciscoJavier SanAndres,

Rafael Rubio,

Jesús Castilla,

Federico Pulido,

Guillermo Palao,

Inmaculada de la Serna de Pedro,

JoseRamon Costa,

A del Palacio

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/374358

Subject(s) - medicine , esophageal candidiasis , incidence (geometry) , opportunistic infection , pneumonia , pneumocystis carinii , tuberculosis , toxoplasmosis , cohort , aids related opportunistic infections , sida , immunology , viral disease , human immunodeficiency virus (hiv) , pneumocystis jirovecii , pathology , physics , optics

Temporal trends in the incidence of opportunistic diseases (ODs) related to acquired immunodeficiency syndrome (AIDS) were studied during 1989-1997 in 1115 outpatients infected with human immunodeficiency virus (331 of whom had AIDS) in a hospital in Madrid, Spain. We analyzed the effect of adherence to antiretroviral therapy and Pneumocystis carinii pneumonia (PCP) prophylaxis on the incidence of OD. Diseases that showed a significant decreasing trend were esophageal candidiasis, pulmonary and extrapulmonary tuberculosis, and cerebral toxoplasmosis. Patients who adhered to antiretroviral therapy had a smaller risk of OD. Patients who adhered to PCP prophylaxis had a reduced risk of cerebral toxoplasmosis and PCP. A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease.

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