Rhinovirus Infections in Hematopoietic Stem Cell Transplant Recipients with Pneumonia | Zendy

Michael G. Ison | Zendy; Frederick G. Hayden | Zendy; Laurent Kaiser | Zendy; Lawrence Corey | Zendy; Michael Boeckh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Rhinovirus Infections in Hematopoietic Stem Cell Transplant Recipients with Pneumonia

Author(s) -

Michael G. Ison,

Frederick G. Hayden,

Laurent Kaiser,

Lawrence Corey,

Michael Boeckh

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/374340

Subject(s) - rhinovirus , medicine , bronchoalveolar lavage , pneumonia , coronavirus , hematopoietic stem cell transplantation , immunology , respiratory tract infections , respiratory tract , respiratory system , lung , transplantation , covid-19 , disease , infectious disease (medical specialty)

Little is known about the impact of human rhinovirus (HRV) and coronavirus infections in hematopoietic stem cell transplant (HSCT) recipients. We tested bronchoalveolar lavage (BAL) samples obtained from HSCT recipients with acute pulmonary infiltrates for HRV (n=122) and coronavirus (n=46) by reverse-transcriptase polymerase chain reaction. HRV RNA was detected in 6 (8%) of 77 patients, and coronavirus RNA was detected in 0 of 46 of BAL samples from HSCT recipients. The fatality rate in HRV-infected patients was high (83%), but all patients had significant coinfections, and the overall mortality rate was not different from that of patients who were negative for HRV in BAL samples. These results suggest that HRV may be a cause of lower respiratory tract infections in HSCT recipients and that its detection in BAL samples is associated with frequent copathogens. Whether the poor prognosis is due to HRV or the copathogen is not clear.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research