De Novo Infection in a Renal Transplant Recipient Caused by Novel Mutants of Hepatitis B Virus Despite the Presence of Protective Anti–Hepatitis B Surface Antibody | Zendy

Mengji Lu | Zendy; Thomas Lorentz | Zendy

Open Access

De Novo Infection in a Renal Transplant Recipient Caused by Novel Mutants of Hepatitis B Virus Despite the Presence of Protective Anti–Hepatitis B Surface Antibody

Author(s) -

Mengji Lu,

Thomas Lorentz

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/373902

Subject(s) - hbsag , hepatitis b virus , virology , immunogenicity , antigenicity , antibody , hepatitis b , immunology , mutant , medicine , virus , antigen , biology , gene , genetics

A renal transplant recipient became persistently positive for hepatitis B virus (HBV) despite preexisting anti-hepatitis B surface (HBs) antibodies. The antigenicity and immunogenicity of wild-type (wt) and mutant HBs antigens (Ags) were compared. In contrast to wt HBsAg, genetic vaccination with mutant HBsAgs did not induce anti-HBs. Thus, mutations within HBsAg may enable HBV to escape immunological control.

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