Open AccessReinfection, Rather than Persistent Infection, in Patients with Chronic Granulomatous Disease
Author(s) -
Shireen V. Guide,
Frida Stock,
Vee J. Gill,
Victoria Anderson,
Harry L. Malech,
John I. Gallin,
Steven M. Holland
Publication year - 2003
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/368388
Subject(s) - chronic granulomatous disease , staphylococcus aureus , microbiology and biotechnology , serratia marcescens , antibiotics , nocardia , serratia , burkholderia , biology , staphylococcal infections , immunology , bacteria , escherichia coli , pseudomonas , biochemistry , genetics , gene
Chronic granulomatous disease (CGD) is characterized by severe recurrent infections with Staphylococcus aureus, certain gram-negative rods, Nocardia species, and fungi. When infections with the same species recur, they may represent relapses or new infections. We collected organisms from infections that occurred between 1992 and 2000 in patients with CGD and determined the biochemical phenotypes, in vitro antibiotic susceptibility patterns, and pulsed-field gel electrophoresis (PFGE) patterns of the organisms causing the initial and recurrent infections. Recurrence of infection with Burkholderia cepacia or Serratia marcescens was caused by a new strain in 9 of 10 cases (P=.001). Recurrent S. aureus infections were caused by new strains in 7 of 8 cases (P=.006). In patients with CGD, recurrence of infection with the same bacterial species after appropriate antibiotic therapy usually represents new infection.
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