Association between Chronic Disseminated Candidiasis in Adult Acute Leukemia and CommonIL4Promoter Haplotypes | Zendy

Eun Hwa Choi | Zendy; Charles B. Foster | Zendy; James G. Taylor | Zendy; Hans Christian Erichsen | Zendy; Renee A. Chen | Zendy; Thomas J. Walsh | Zendy; VeliJukka Anttila | Zendy; Tapani Ruutu | Zendy; Aarno Palotie | Zendy; Stephen J. Chanock | Zendy

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Association between Chronic Disseminated Candidiasis in Adult Acute Leukemia and CommonIL4Promoter Haplotypes

Author(s) -

Eun Hwa Choi,

Charles B. Foster,

James G. Taylor,

Hans Christian Erichsen,

Renee A. Chen,

Thomas J. Walsh,

VeliJukka Anttila,

Tapani Ruutu,

Aarno Palotie,

Stephen J. Chanock

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/368345

Subject(s) - haplotype , immunology , biology , leukemia , medicine , genetics , genotype , gene

Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/-33C) was overrepresented in patients with CDC (P= .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/-33T) appeared to be protective against CDC (P= .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

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