Suppression byCandida albicansβ‐Glucan of Cytokine Release from Activated Human Monocytes and from T Cells in the Presence of Monocytes | Zendy

Yukari Nakagawa | Zendy; Naohito Ohno | Zendy; Toshimi Murai | Zendy

Open Access

Suppression byCandida albicansβ‐Glucan of Cytokine Release from Activated Human Monocytes and from T Cells in the Presence of Monocytes

Author(s) -

Yukari Nakagawa,

Naohito Ohno,

Toshimi Murai

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/368334

Subject(s) - candida albicans , peripheral blood mononuclear cell , monocyte , cytokine , proinflammatory cytokine , immunology , interleukin , microbiology and biotechnology , interferon gamma , biology , chemistry , in vitro , inflammation , biochemistry

The effect of a soluble beta-glucan from Candida albicans (CSBG) on cytokine production by cultured human peripheral blood mononuclear cells (PBMC) was assessed. CSBG induced a slight increase in the spontaneous release of proinflammatory cytokines, such as interleukin (IL)-6, but significantly suppressed endotoxin-induced IL-6 production in cultures of PBMC and monocytes isolated from PBMC. CSBG also suppressed the release of type 1 cytokines, IL-2, and interferon-gamma. These findings suggest that CSBG suppresses monocyte functions directly and thus suppresses T cell function indirectly. CSBG may play a role in the development of candidiasis.

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