Acquired T‐helper 1 Lymphocyte Anergy Following Infection withMycobacterium ulcerans | Zendy

Travis M. Gooding | Zendy; Andrew S. Kemp | Zendy; Roy M. RobinsBrowne | Zendy; M. G. Smith | Zendy; Paul D. R. Johnson | Zendy

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Acquired T‐helper 1 Lymphocyte Anergy Following Infection withMycobacterium ulcerans

Author(s) -

Travis M. Gooding,

Andrew S. Kemp,

Roy M. RobinsBrowne,

M. G. Smith,

Paul D. R. Johnson

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/368315

Subject(s) - mycobacterium ulcerans , medicine , immunology , buruli ulcer , peripheral blood mononuclear cell , microbiology and biotechnology , in vitro , biology , pathology , disease , biochemistry

We describe a patient with acquired T-helper lymphocyte anergy to mycobacteria following infection with Mycobacterium ulcerans. Before infection, the patient's peripheral blood mononuclear cells responded to in vitro stimulation with M. ulcerans by producing Th1 cytokines, but, after she developed an ulcer, the response was shifted toward production of Th2 cytokines. Immunomodulatory therapy may be an effective intervention for Buruli ulcer.

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