Tenofovir‐Related Nephrotoxicity in Human Immunodeficiency Virus–Infected Patients: Three Cases of Renal Failure, Fanconi Syndrome, and Nephrogenic Diabetes Insipidus | Zendy

Alexandre Karras | Zendy; Matthieu Lafaurie | Zendy; André Furco | Zendy; A. Bourgarit | Zendy; D Droz | Zendy; D. Séréni | Zendy; Christophe Legendre | Zendy; Frank Martinez | Zendy; JeanMichel Molina | Zendy

Open Access

Tenofovir‐Related Nephrotoxicity in Human Immunodeficiency Virus–Infected Patients: Three Cases of Renal Failure, Fanconi Syndrome, and Nephrogenic Diabetes Insipidus

Author(s) -

Alexandre Karras,

Matthieu Lafaurie,

André Furco,

A. Bourgarit,

D Droz,

D. Séréni,

Christophe Legendre,

Frank Martinez,

JeanMichel Molina

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/368314

Subject(s) - nephrogenic diabetes insipidus , medicine , tubulopathy , fanconi syndrome , glycosuria , nephrotoxicity , renal tubular acidosis , hypophosphatemia , hypouricemia , diabetes insipidus , proteinuria , aminoaciduria , urology , renal biopsy , kidney , gastroenterology , endocrinology , diabetes mellitus , acidosis , uric acid , urine

We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria).

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