Use of an Open‐Reading Frame–SpecificCampylobacter jejuniDNA Microarray as a New Genotyping Tool for Studying Epidemiologically Related Isolates | Zendy

Edward E. Leonard | Zendy; Tohru Takata | Zendy; Martin J. Blaser | Zendy; Stanley Falkow | Zendy; Lucy S. Tompkins | Zendy; Erin C. Gaynor | Zendy

Open Access

Use of an Open‐Reading Frame–SpecificCampylobacter jejuniDNA Microarray as a New Genotyping Tool for Studying Epidemiologically Related Isolates

Author(s) -

Edward E. Leonard,

Tohru Takata,

Martin J. Blaser,

Stanley Falkow,

Lucy S. Tompkins,

Erin C. Gaynor

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/368268

Subject(s) - campylobacter jejuni , biology , typing , open reading frame , genotyping , rapd , genetics , microarray , campylobacter , dna microarray , serotype , dna , gene , computational biology , microbiology and biotechnology , genotype , genetic diversity , bacteria , gene expression , medicine , population , environmental health , peptide sequence

Findings from use of an open-reading frame-specific Campylobacter jejuni DNA microarray to investigate genetic diversity among clinical isolates associated with 5 independent clusters of infection were compared with data from random amplified polymeric DNA (RAPD) and Penner serotyping analyses. The DNA microarray provides a highly specific epidemiological typing tool for analysis of C. jejuni isolates and reveals both divergent and highly conserved gene classes among isolates.

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