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For the 127 Spanish patients enrolled in the Combine Study, a resistance substudy was performed with 100 (79%) plasma samples obtained at baseline and with 18 samples obtained from 19 patients at the time they experienced treatment failure. At baseline, primary mutations to nonnucleoside reverse-transcriptase inhibitors and protease inhibitors were not detected, whereas mutations to nucleoside reverse-transcriptase inhibitors were observed in 10% of patients. At failure, mutations were detected in 7 of 16 patients. An agreement in the results of virtual and real phenotypes was observed in the 93 samples in which both tests were performed.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Genotype and Phenotype at Baseline and at Failure in Human Immunodeficiency Virus–Infected Antiretroviral‐Naive Patients in a Randomized Trial Comparing Zidovudine and Lamivudine plus Nelfinavir or Nevirapine