Postnatal Human Herpesvirus 8 and Human Immunodeficiency Virus Type 1 Infection in Mothers and Infants from Zambia | Zendy

Brad Brayfield | Zendy; Saul Phiri | Zendy; Chipepo Kankasa | Zendy; Jubra Muyanga | Zendy; Hamakwa Mantina | Zendy; Geoffrey Kwenda | Zendy; John T. West | Zendy; Ganapati Bhat | Zendy; D.B. Marx | Zendy; Winslow Klaskala | Zendy; Charles D. Mitchell | Zendy; Charles Wood | Zendy

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Postnatal Human Herpesvirus 8 and Human Immunodeficiency Virus Type 1 Infection in Mothers and Infants from Zambia

Author(s) -

Brad Brayfield,

Saul Phiri,

Chipepo Kankasa,

Jubra Muyanga,

Hamakwa Mantina,

Geoffrey Kwenda,

John T. West,

Ganapati Bhat,

D.B. Marx,

Winslow Klaskala,

Charles D. Mitchell,

Charles Wood

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/367985

Subject(s) - in utero , transmission (telecommunications) , medicine , virus , pregnancy , human immunodeficiency virus (hiv) , immunology , virology , peripheral blood mononuclear cell , human herpesvirus , immunodeficiency , pediatrics , biology , fetus , immune system , in vitro , engineering , biochemistry , genetics , electrical engineering

The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.

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