Outbreak of Meningococcal Disease Caused by PorA‐Deficient Meningococci | Zendy

Arie van der Ende | Zendy; C. T. P. Hopman | Zendy; Wendy Keijzers | Zendy; Lodewijk Spanjaard | Zendy; Esther B Lodder | Zendy; P. H. J. van Keulen | Zendy; J. Dankert | Zendy

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Outbreak of Meningococcal Disease Caused by PorA‐Deficient Meningococci

Author(s) -

Arie van der Ende,

C. T. P. Hopman,

Wendy Keijzers,

Lodewijk Spanjaard,

Esther B Lodder,

P. H. J. van Keulen,

J. Dankert

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/367899

Subject(s) - meningococcal disease , outbreak , neisseria meningitidis , virology , typing , meningitis , transmission (telecommunications) , neisseriaceae , microbiology and biotechnology , medicine , meningococcal infections , biology , pediatrics , antibiotics , bacteria , genetics , electrical engineering , engineering

An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.

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