Adenovirus DNA in Serum of Children Hospitalized Due to an Acute Respiratory Adenovirus Infection | Zendy

Stephan W. Aberle | Zendy; Judith H. Aberle | Zendy; Christoph Steininger | Zendy; Susanne MatthesMartin | Zendy; Elisabeth Pracher | Zendy; Therese PopowKraupp | Zendy

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Adenovirus DNA in Serum of Children Hospitalized Due to an Acute Respiratory Adenovirus Infection

Author(s) -

Stephan W. Aberle,

Judith H. Aberle,

Christoph Steininger,

Susanne MatthesMartin,

Elisabeth Pracher,

Therese PopowKraupp

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/367808

Subject(s) - adenovirus infection , virology , polymerase chain reaction , adenoviridae , mastadenovirus , respiratory tract , respiratory system , respiratory tract infections , virus , immunology , biology , dna , medicine , gene , genetic enhancement , biochemistry , genetics

Serum samples from 68 immunocompetent infants (mean age, 12.6 months) with an acute adenovirus infection of the respiratory tract (39 experiencing their first adenovirus infection) were tested for the presence of adenovirus DNA, to investigate whether viral dissemination via the blood is usually present in the immunocompetent patient. Using a nested polymerase chain reaction assay, adenovirus DNA could be detected in acute-phase serum samples from 28 (41%) children. Adenovirus DNA was never found in follow-up serum samples, indicating a short period ( approximately 1 week) of viral dissemination. In children experiencing their first adenovirus infection, viral DNA could be detected in 72% of the acute-phase serum samples collected within the first week after onset of symptoms. Adenovirus DNA could also be detected in 25% of the acute-phase serum samples from patients with reinfection.

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