Limited Protective Effect of the CCR5Δ32/CCR5Δ32 Genotype on Human Immunodeficiency Virus Infection Incidence in a Cohort of Patients with Hemophilia and Selection for Genotypic X4 Virus | Zendy

Astrid K. N. Iversen | Zendy; C Christiansen | Zendy; Jørn Attermann | Zendy; Jesper EugenOlsen | Zendy; Sam Schulman | Zendy; Erik Berntorp | Zendy; Jørgen Ingerslev | Zendy; Lars Fugger | Zendy; E. Scheibel | Zendy; Lillian Tengborn | Zendy; Jan Gerstoft | Zendy; Ebbe Dickmeiss | Zendy; Arne Svejgaard | Zendy; Peter Skinhøj | Zendy

Open Access

Limited Protective Effect of the CCR5Δ32/CCR5Δ32 Genotype on Human Immunodeficiency Virus Infection Incidence in a Cohort of Patients with Hemophilia and Selection for Genotypic X4 Virus

Author(s) -

Astrid K. N. Iversen,

C Christiansen,

Jørn Attermann,

Jesper EugenOlsen,

Sam Schulman,

Erik Berntorp,

Jørgen Ingerslev,

Lars Fugger,

E. Scheibel,

Lillian Tengborn,

Jan Gerstoft,

Ebbe Dickmeiss,

Arne Svejgaard,

Peter Skinhøj

Publication year - 2003

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/345881

Subject(s) - genotype , virus , virology , biology , immunology , population , viral disease , lentivirus , medicine , gene , genetics , environmental health

The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research