Human Herpesvirus 6B Infection of the Large Intestine of Patients with Diarrhea | Zendy

Kiyoko Amo | Zendy; Keiko TanakaTaya | Zendy; Reiko Inagi | Zendy; Hiromi Miyagawa | Zendy; Hiroko Miyoshi | Zendy; Ikuko Okusu | Zendy; Junji Sashihara | Zendy; Junichi Hara | Zendy; Masahiro Nakayama | Zendy; Koichi Yamanishi | Zendy; Shintaro Okada | Zendy

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Human Herpesvirus 6B Infection of the Large Intestine of Patients with Diarrhea

Author(s) -

Kiyoko Amo,

Keiko TanakaTaya,

Reiko Inagi,

Hiromi Miyagawa,

Hiroko Miyoshi,

Ikuko Okusu,

Junji Sashihara,

Junichi Hara,

Masahiro Nakayama,

Koichi Yamanishi,

Shintaro Okada

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/345464

Subject(s) - peripheral blood mononuclear cell , diarrhea , medicine , human herpesvirus , histiocyte , large intestine , transplantation , in situ hybridization , small intestine , herpesviridae , pathology , virus , virology , immunology , viral disease , biology , in vitro , gene , biochemistry , gene expression

Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.

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